agonist

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Related to Partial agonist: therapeutic index, Inverse agonist

ag·o·nist

 (ăg′ə-nĭst)
n.
1. Physiology A contracting muscle that is resisted or counteracted by another muscle, the antagonist.
2. A substance that can combine with a receptor on a cell to initiate signal transduction.
3. One involved in a struggle or competition.

[Late Latin agōnista, contender, from Greek agōnistēs, from agōn, contest; see agony.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

agonist

(ˈæɡənɪst)
n
1. (Physiology) any muscle that is opposed in action by another muscle. Compare antagonist2
2. a competitor, as in an agon
[C17: from Greek agōn agon]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

ag•o•nist

(ˈæg ə nɪst)

n.
1. a person engaged in a contest, conflict, struggle, etc., esp. the protagonist in a literary work.
2. a person who is torn by inner conflict.
3. a contracting muscle whose action is opposed by another muscle. Compare antagonist (def. 3).
4. a chemical substance capable of activating a receptor to induce a full or partial pharmacological response. Compare antagonist (def. 5).
[1620–30; < Late Latin agōnista < Greek agōnistḗs contestant =agṓn agon + -istēs -ist]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.

ag·o·nist

(ăg′ə-nĭst)
A muscle that actively contracts to produce a desired movement. Compare antagonist.
The American Heritage® Student Science Dictionary, Second Edition. Copyright © 2014 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

agonist

one who contends for a prize in public games. — agonistic, agonistical, adj.
See also: Athletics
-Ologies & -Isms. Copyright 2008 The Gale Group, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.agonist - the principal character in a work of fictionagonist - the principal character in a work of fiction
antihero - a protagonist who lacks the characteristics that would make him a hero (or her a heroine)
2.agonist - someone involved in a contest or battle (as in an agon)agonist - someone involved in a contest or battle (as in an agon)
contestant - a person who participates in competitions
adversary, antagonist, opposer, resister, opponent - someone who offers opposition
3.agonist - a muscle that contracts while another relaxesagonist - a muscle that contracts while another relaxes; "when bending the elbow the biceps are the agonist"
antagonistic muscle - (physiology) a muscle that opposes the action of another; "the biceps and triceps are antagonistic muscles"
4.agonist - (biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction
drug - a substance that is used as a medicine or narcotic
biochemistry - the organic chemistry of compounds and processes occurring in organisms; the effort to understand biology within the context of chemistry
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations
agonista
agonista
References in periodicals archive ?
Specific values obtained from laboratory assays using contaminated samples are likely to overestimate both the potency and the maximal effect of partial agonist ligands, in turn overestimating the REP and TEF values.
"There are two possible explanations for this finding: tamoxifen resistance might be overcome by a change in treatment; or aromatase inhibitors might simply be a better treatment option, since they reduce peripheral estrogen concentrations to extremely low levels, whereas tamoxifen is a partial agonist," wrote the investigators, who were led by Raimund Jakesz, M.D., of Vienna Medical University, Austria.
Dosage windows could be difficult to understand pharmacologically, but for a partial agonist the presumed mechanism could be more evident.
This merger will create a clinical-stage company focused on clinical and commercial development of cytisine, a selective nicotine receptor partial agonist currently in late-stage development for smoking cessation.
While the mechanism of action of VRAYLAR in schizophrenia and bipolar I disorder is unknown, the efficacy of VRAYLAR could be mediated through a combination of partial agonist activity at central dopamine D?
Cariprazine is a dopamine-2 and dopamine-3 receptor partial agonist, tending toward the D3 receptor.
Varenicline, a nicotinic receptor partial agonist marketed as Chantix by Pfizer, was approved in 2006.
"'Unlike other antidepressants, Viibryd [vilazodone hydrochloride] is the first and only drug that is both a potent selective serotonin reuptake inhibitor and serotonin 1A [5-[HT.sub.1A]] receptor partial agonist in one single molecule," said Clinical Data's CEO Drew Fromkin during a call with analysts and investors on Jan.
The central hypothesis driving these studies was that analysis of AhR agonist activity in neat serum, as a cumulative measure of AhR ligand (agonist, partial agonist, antagonist) exposure, would provide a broader context for interpretation of GC/MS-determined TEQs and exposure assessment.
Tegaserod, a 5-H[T.sub.4] receptor partial agonist, activates 5-H[T.sub.4] receptors in the gut, increasing GI motility, according to Novartis.