donepezil

do·nep·e·zil

(dō-nĕp′ə-zĭl′)

A drug, C₂₄H₂₉NO₃, that inhibits acetylcholinesterase and is used in its hydrochloride form to treat mild to moderate dementia caused by Alzheimer's disease.

[Perhaps (in)done, a ketone (ind(ene) + -one) + (pi)pe(ridine) + alteration of (ben)zyl.]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

donepezil

(dəˈnɛpəzɪl)

a drug used to treat dementia

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

Translations

donepezil

n donepezilo

References in periodicals archive ?

At present, cerebroselective anticholinesterase drugs such as donepezil, rivastigmine, and galantamine are mainstay therapy in AD.

Evaluation of the antioxidant activity of donepezil - in vitro study

Food and Drug Administration's approval of Corium's lead product candidate, Corplex Donepezil, for the treatment of Alzheimer's disease, prior to March 31, 2020.

Gurnet Point buys Corium for $12.50 per share in $504M deal

The affected drugs include: Azithromycin, Donepezil, Haloperidol, Imipramine HCl, Isosorbide Dinitrate, Naratriptan, Ondansetron, Perphenazine, and Risperidone.

Novartis and Sandoz Recall Non-Compliant Blister Packs

Several case reports showed that donepezil could lead rarely to serious bradycardia needing pacemaker implantation and fatal ventricular arrhythmia (torsade de pointes (TdP)) [7,8].

Electrocardiogram Changes of Donepezil Administration in Elderly Patients with Ischemic Heart Disease

Cholinergic transmission is the main target for most of the current symptomatic therapies in neurodegenerative diseases, in the form of ACh esterase (AChE) inhibitors such as donepezil. The pharmacological model based on scopolamine, which temporarily blocks muscarinic cholinergic receptors in the brain, is widely regarded as a standard model for investigating cognitive deficits and may be useful in the search for improved procognitive drugs.

Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late "P300-Like" Event-Related Potential in Rats

29, 2017) that ranked the safety and effectiveness of four drugs currently used to treat Alzheimer's disease (AD) symptoms found that donepezil (Aricept[R]) was most likely to improve cognition.

AD Drug Effectiveness Examined

"Since odour identification tests have been shown to predict progression to Alzheimer's, we hypothesised that these tests would also allow us to discover which patients with MCI would be more likely to improve with donepezil treatment."

Declining sense of smell can identify patients with mild cognitive impairment

M2 EQUITYBITES-September 1, 2017-Zydus Cadila granted final FDA approval to market Donepezil Hydrochloride tablets

Zydus Cadila granted final FDA approval to market Donepezil Hydrochloride tablets

M2 PHARMA-September 1, 2017-Zydus Cadila granted final FDA approval to market Donepezil Hydrochloride tablets

Zydus Cadila granted final FDA approval to market Donepezil Hydrochloride tablets

Donepezil is a drug used in the palliative treatment of AD.

Activation of Two Different Drugs Used in Alzheimer's Disease Treatment on Human Carbonic Anhydrase Isozymes I and II Activity: an In Vitro Study/Alzheimer Hastaliginin Tedavisinde Kullanilan Iki Farkli Ilacin Insan Karbonik Anhidraz I ve II Izoenzim Aktiviteleri Uzerindeki Aktivasyonu: In Vitro Calisma

Keywords: Alzheimer Disease, pharmacist, pharmacotherapy applications, caregivers, donepezil