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Effects of toluene on the morphology of neuropeptide secretory neurons of the rat hypothalamus

Shen, C.L.; Ting, W.H.; Chang, T.K.

Proceedings of the National Science Council Republic of China. Part B Life Sciences 16(4): 162-168

1992

ISSN/ISBN: 0255-6596
PMID: 1305769
Document Number: 392069
The effect of toluene on the hypothalamic hormone-secreting neurons and neurotransmitter-containing fibers in the rat was investigated by immunohistochemical methods. Multiple intraperitoneal injections of toluene (totally 7.5 ml) led to significant decreases of the neuronal numbers of vasopressin, oxytocin and neuropeptide Y in the preoptic and hypothalamic areas. The densities of vasopressin, oxytocin, norepinephrine and neuropeptide Y immunoreactive fibers of the toluene dose group decreased markedly in the median eminence. In contrast, LHRH neurons remained unchanged.

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