Decreased uptake of low density lipoprotein by LLC-PK cells cultured at low magnesium concentration
Mahfouz, M.M.; Smith, T.L.; Kummerow, F.A.
Magnesium Research 5(4): 249-254
1992
ISSN/ISBN: 0953-1424 PMID: 1296759 Document Number: 390913
LLC-PK cells grown in tissue culture on medium containing normal or deficient amounts of magnesium were presented with 125I-low density lipoprotein (LDL) and the uptake determined. Total LDL uptake by Mg-deficient cells decreased as the magnesium concentration decreased. The receptor binding of LDL and the internalization of LDL by the Mg-deficient cells were reduced. Degradation of LDL by Mg-deficient cells, when corrected for the reduced uptake, was less affected.
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