Acute respiratory failure during pneumonia induced by Sendai virus
van Daal, G.J.; Eijking, E.P.; So, K.L.; Fievez, R.B.; Sprenger, M.J.; van Dam, D.W.; Erdmann, W.; Lachmann, B.
Advances in Experimental Medicine and Biology 316: 319-326
1992
ISSN/ISBN: 0065-2598 PMID: 1337653 Document Number: 390245
In this study a model of acute respiratory failure due to viral pneumonia in rats, closely resembling ARDS, is presented. Severe respiratory failure with lethal outcome in four days was induced by infection concentrated Sendai virus aerosol. This model permits evaluation of different therapeutical approaches for improving gas exchange during ARDS. Furthermore, preliminary results of surfactant substitution therapy in this model are presented.
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