Top Abstract Purchase Related
Home
>
Node
>
Subnode

Coding part of the son gene small transcript contains four areas of complete tandem repeats

Bliskovskiĭ, V.V.; Berdichevskiĭ, F.B.; Tkachenko, A.V.; Belova, M.E.; Chumankov, I.M.

Molekuliarnaia Biologiia 26(4): 793-806

1992

ISSN/ISBN: 0026-8984
PMID: 1435773
Document Number: 389842
Overlapping cDNA clones for the smaller son gene transcript were isolated by several steps of human placenta cDNA library walking. Here we report the structure of repeats that exist at the long open reading, present in the structure of this smaller (5.6 kb) transcript of human gene son. We were able to identify in this transcript four areas of complete tandem repeats, formed by several steps of duplication. For three of them the extent of homology between amino acid sequences of repeated elements is higher than between their nucleic acid sequences. It means that amino acid sequences of repeated elements are conserved, that could reflect the structural significance for the function of hypothetical protein product of human gene son. On the basis of the results of analysis we proposed the model for the formation of repeats by processes of duplication, mutation and natural selection pressure at the expressed protein level.

Document emailed within 1 workday
Secure & encrypted payments

Kravchenko, S.A.; Livshits, L.A. 1993: An analysis of mutations in the 7th, 10th and 11th exons and of the polymorphism of the 4 nucleotide tandem repeats from the 3' end of the 6th intron of the CFTR gene in families from Ukraine with a high risk of mucoviscidosis Tsitologiia i Genetika 27(4): 72-77
Mizuno, T. 1984: Regulation of gene expression by a small RNA transcript (micRNA): osmoregulation in E. coli Seikagaku. Journal of Japanese Biochemical Society 56(2): 113-119
Kytnarova, J.; Vesela, K.; Zlatohlavkova, B.; Dohnalova, A.; Fedorova, M.; Krsek, M.; Zeman, J. 2009: Cytosine-Adenosine (CA)n repeats polymorphism in IGF-i gene and early growth in infants born appropriate and small for gestational age Neuro Endocrinology Letters 30(4): 501-505
Bazzocchi, C.; Lecchi, C.; Kramer, L.H.; Genchi, C.; Bandi, C. 2004: Sequencing of the complete gene coding for the GroEL of the Wolbachia of Dirofilaria immitis and expression and purification of the recombinant protein Parassitologia 46(3): 307-310
Abramian, L.G.; Arkhipova, I.R.; Ambartsumian, N.S. 1993: Long terminal repeats of drosophila mobile elements direct transcript ion in Escherichia coli cells Molekuliarnaia Biologiia 27(2): 358-362
Bliskovskiĭ, V.V. 1992: Tandem DNA repeats in the vertebrate genome: structure, possible mechanisms of formation and evolution Molekuliarnaia Biologiia 26(5): 965-982
Moravcova, J.; Regner, J.; Mouckova, D.; Fiser, K.; Zmekova, V.; Malacova, R.; Michalova, K.; Klamova, H. 2005: Disease status in patients with chronic myeloid leukemia is better characterized by BCR-ABL/BCR transcript ratio than by BCR-ABL transcript level, which may suggest a role of normal BCR gene in the disease pathogenesis Neoplasma 52(2): 119-125
Cole, R.A.; Williams, K.L. 1992: Tandem repeats in extrachromosomal ribosomal DNA of Dictyostelium discoideum, resulting from chromosomal mutations Genetics 130(4): 757-769
Moriyama, M.; Ogawa, K.; Nishimori, K.; Uchiya, K.; Ito, T.; Yagi, T.; Nakashima, I.; Nakagawa, T.; Tarumi, O.; Nikai, T. 2006: Usefulness of variable numbers of tandem repeats typing in clinical strains of Mycobacterium avium Kekkaku: 81(9): 559-566
Nosikov, V.V.; Ovchinnikov, I.V.; Gavrilov, D.K.; Chelnokova, M.V. 1991: The use of synthetic oligonucleotide primers for amplification of a variable number of tandem repeats loci for paternity testing Nucleic Acids Symposium Series 24: 219
Chistiakov, D.A.; Gavrilov, D.K.; Ovchinnikov, I.V.; Nosikov, V.V. 1993: Analysis of the distribution of alleles of four hypervariable tandem repeats among unrelated Russian individuals living in Moscow, using the polymerase chain reaction Molekuliarnaia Biologiia 27(6): 1304-1314
Borrello, M.G.; Pierotti, M.A.; Tamborini, E.; Biassoni, D.; Rizzetti, M.G.; Pilotti, S.; Della Porta, G. 1992: DNA methylation of coding and non-coding regions of the human H-RAS gene in normal and tumor tissues Oncogene 7(2): 269-275
Jaeger, D.A.; Loeb, S.; Turner, S.E.; Bound, J. 1998: Coding geographic areas across census years: creating consistent definitions of metropolitan areas Working Paper Series 6772: 43 P
Finger, A.L. 1998: Coding, Part 3. get the highest coding you're entitled to Medical Economics 75(10): 73
Noegel, A.; Gerisch, G.; Stadler, J.; Westphal, M. 1986: Complete sequence and transcript regulation of a cell adhesion protein from aggregating Dictyostelium cells EMBO Journal 5(7): 1473-1476
Li, D.; Song, Y.-m.; Zhan, Q.-m. 2010: Specifically up-regulated non-coding RNA gene HULC in tumor cell lines and its effects on the expression of neighboring gene SLC35B3 Zhonghua Yi Xue Za Zhi 90(44): 3156-3159
Breiteneder, H.; Pettenburger, K.; Bito, A.; Valenta, R.; Kraft, D.; Rumpold, H.; Scheiner, O.; Breitenbach, M. 1989: The gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene EMBO Journal 8(7): 1935-1938
Swanton, M.T.; Greslin, A.F.; Prescott, D.M. 1980: Arrangement of coding and non-coding sequences in the DNA molecules coding for rRNAs in Oxytricha sp. DNA of ciliated protozoa. VII Chromosoma 77(2): 203-215
Korobko, E.V.; Kalinichenko, S.V.; Shepelev, M.V.; Zborovskaia, I.B.; Allakhverdiev, A.K.; Zinov'eva, M.V.; Vinogradova, T.V.; Sverdlov, E.D.; Korobko, I.V. 2007: Suppression of WIFI transcript and protein in non-small cell lung carcinomas Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 2007(2): 13-18
Roshina, M.P.; Loginova, N.N.; Devin, A.B.; Gvozdev, V.A. 2008: Heterochromatic DNA repeats in Drosophila and unusual gene silencing in yeast cells Genetika 44(6): 752-760