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Evaluation of monoclonal/polyclonal ratio in kidney-transplanted patients treated with cyclosporine

Capone, D.; Stanziale, P.; Balletta, M.M.; Imperatore, P.; De Marino, V.; Pisanti, N.

International Journal of Clinical Pharmacology Research 12(3): 123-128

1992

ISSN/ISBN: 0251-1649
PMID: 1473878
Document Number: 389029
Fifty-seven kidney-transplanted outpatients, treated with cyclosporine alone or associated with azathioprine, prednisone, or methylprednisolone, were submitted to a monthly follow-up in order to determine cyclosporine blood levels and the monoclonal/polyclonal (MIP) ratio. Only methylprednisolone was able to modify the MIP ratio. This drug increased the MIP ratio, suggesting a cyclosporine metabolic inhibition. This effect disappeared in a few months in spite of the continuation of methylprednisolone treatment.

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