Colourized microscopy image of the protist Tritrichomonas foetus

True cyst formation underlies persistence and drug tolerance in Tritrichomonas foetus

The protist Tritrichomonas foetus can cause disease in cows and cats. Lucrecia Iriarte et al. show that, under stress, the parasite forms cysts that reduce drug susceptibility.

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    This Nature Conference, held in Nanjing in October 2025, explores how the integration of AI with biological sciences unlocks immense potential for groundbreaking discoveries. It will cover multi-modal data mining, protein engineering, molecular and cellular engineering, large language models, foundation models for understanding complex biological systems and diseases, and the emergence of life.

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  • Here, the authors propose structured operator learning with spectral decomposition, sparse regression, and cross-view regularization to recover stable, interpretable governing equations under noisy, high-dimensional, and distribution-shifted data.

    • Dongni Jia
    • Shuai Li
    • Xiaofeng Zhou
    ArticleOpen Access
  • Navigation services concentrate traffic onto a few roads as adoption increases. Simulations in Florence, Milan, and Rome show route diversity drops by up to 14% at full adoption, and CO2 benefits vanish or reverse beyond a city- and service-specific threshold.

    • Giuliano Cornacchia
    • Mirco Nanni
    • Luca Pappalardo
    ArticleOpen Access
  • This study shows that declining national energy intensity of GDP does not always imply global decarbonization, as its reductions often stem from offshoring energy-intensive production, highlighting the need to account for global supply chains.

    • Claudia Amadei
    • Cesare Dosi
    • Francesco Jacopo Pintus
    ArticleOpen Access
  • This study compiles a region-wide database of residential electricity tariffs in Sub-Saharan Africa and shows that current grid expansion strategies may create electrification traps, leaving electricity unaffordable for households and financially unsustainable for utilities.

    • Yidan Kou
    • Stephanie Hirmer
    • Florian Egli
    ArticleOpen Access

Subjects within Scientific community and society

  • Hybrid modelling using machine learning can help improve the robustness and comprehensiveness of economic impact assessments of climate change by combining data with theory, bridging silos across social, economic, and financial systems, and linking micro- and macroeconomic scales.

    • Anton Orlov
    • Jana Sillmann
    CommentOpen Access
  • Online behavioural research faces a growing methodological and epistemic threat as participants increasingly rely on large language models: LLM Pollution. Amid accumulating empirical evidence of contamination, we introduce a conceptual framework that distinguishes three variants — Partial LLM Mediation, Full LLM Delegation, and LLM Spillover. Their interaction distorts samples, biases inferences, and fuels an escalating methodological arms race. We outline mitigation strategies spanning researcher practices, platform accountability, and community adaptation.

    • Raluca Rilla
    • Tobias Werner
    • Anne-Marie Nussberger
    CommentOpen Access
  • Genomic data could transform healthcare, but African populations are underrepresented, currently limiting benefits. Here the authors highlight how addressing political, financial, and social barriers and advancing equitable national genome projects is essential.

    • Mohamed Zahir Alimohamed
    • Ghada El-Kamah
    • Michele Ramsay
    CommentOpen Access
  • This comment introduces four governance actions that consider how sustainability, evaluation, safety, and cooperation can be integrated into the transformation of open-source AI, thereby reducing uncertainties and challenges posed by open-source AI for sustainable global prosperity.

    • Min Chen
    • Kai Wu
    • Guonian Lü
    CommentOpen Access
  • Consortia of microbial isolates, also known as synthetic communities (SynComs), are increasingly used to study and harness microbe-microbe and microbe-host interactions. Since “synthetic” potentially evokes negative connotations, we propose adopting the term “Defined Microbial Community” for practical applications.

    • Hanna Koch
    • Thomas Clavel
    • Angela Sessitsch
    CommentOpen Access
  • Avoiding danger even when competing goals are imminent supports survival, yet the mechanisms orchestrating this behavioral override remain unclear. Macdonald and colleagues1 describe a thalamostriatal microcircuit that modulates terminal dopamine release, bypassing canonical midbrain dopamine circuitry to prioritize safety.

    • Rachel E. Clarke
    • James M. Otis
    CommentOpen Access
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