KEGG ENZYME: 4.1.1.93

ENZYME: 4.1.1.93

Entry

EC 4.1.1.93                 Enzyme

Name

pyrrole-2-carboxylate decarboxylase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

pyrrole-2-carboxylate carboxy-lyase

Reaction(IUBMB)

(1) pyrrole-2-carboxylate = pyrrole + CO2 [RN:R09794];
(2) pyrrole-2-carboxylate + H2O = pyrrole + HCO3- [RN:R09795]

Reaction(KEGG)

R09794 R09795

Substrate

pyrrole-2-carboxylate [CPD:C05942];
H2O [CPD:C00001]

Product

pyrrole [CPD:C19907];
CO2 [CPD:C00011];
HCO3- [CPD:C00288]

Comment

The enzyme catalyses both the carboxylation and decarboxylation reactions. However, while bicarbonate is the preferred substrate for the carboxylation reaction, decarboxylation produces carbon dioxide. The enzyme is activated by carboxylic acids.

History

EC 4.1.1.93 created 2011

Orthology

K28958

pyrrole-2-carboxylate decarboxylase

Genes

YRE:	HEC60_12825

SMAC:

SMDB11_2383

SMW:	SMWW4_v1c31660

SMAF:

D781_0929

SRZ:	AXX16_4170

SERM:

CLM71_04540

SSUR:

ATE40_012400

SRHZ:

FO014_05245

SNEM:

NLX84_15865

SGRI:

SGBXF1_00893(ubiD_2)

SERN:

GUC32_15375

SERT:

TAN611_1000(hudA)

PAE:

PA0254

PAEV:

N297_260(ubiD)

PAEI:

N296_260(ubiD)

PAU:	PA14_03130

PAG:	PLES_02511

PAF:	PAM18_0250

PNC:	NCGM2_0260

PAEB:

NCGM1900_0245

PDK:	PADK2_01260

PSG:	G655_01260

PRP:	M062_01250

PAEP:

PA1S_01305

PAER:

PA1R_gp3768

PAEM:

U769_01275

PAEL:

T223_01260

PAES:

SCV20265_0258

PAEU:

BN889_00303

PAEG:

AI22_02640

PAEC:

M802_259(ubiD)

PAEO:

M801_260(ubiD)

SECH:

B18_06640

PAP:	PSPA7_0338

PPAA:

B7D75_01280

PSEP:

C4K39_5431

PPII:

QL104_18320

BURF:

Bsp3421_000539

PSAA:

QEN71_33680

BSYM:

CIT39_03225

XDI:	EZH22_15485

NIA:	A8C56_18615

PCHI:

PC41400_18640

CHYL:

CE91St63_05910(hudA)

CBIL:

EUBC25_20380(hudA)

MSER:

MTY59_45200(hudA)

MPAA:

MKK62_26050

MMAG:

MMAD_01750(hudA)

MIZ:	BAB75_13980

STRT:

A8713_30820

SALU:

DC74_625

SALL:

SAZ_03640

SVU:	B1H20_31960

SVQ:	N6Q81_01800

SCAL:

I6J39_31765

SLON:

LGI35_40670

SLUO:

PS467_32350

SCAJ:

O1G22_20235

KSK:

KSE_10520

MIK:	FOE78_15720

ATL:	Athai_44370(hudA)

CAI:

Caci_1073

JCY:	M6B22_19420

» show all

Reference

1 [PMID:9826198]

Authors

Wieser M, Fujii N, Yoshida T, Nagasawa T

Title

Carbon dioxide fixation by reversible pyrrole-2-carboxylate decarboxylase from Bacillus megaterium PYR2910.

Journal

Eur J Biochem 257:495-9 (1998)
DOI:10.1046/j.1432-1327.1998.2570495.x

Reference

2 [PMID:9654100]

Authors

Omura H, Wieser M, Nagasawa T

Title

Pyrrole-2-carboxylate decarboxylase from Bacillus megaterium PYR2910, an organic-acid-requiring enzyme.

Journal

Eur J Biochem 253:480-4 (1998)
DOI:10.1046/j.1432-1327.1998.2530480.x

Reference

Authors

Wieser M, Yoshida T, Nagasawa T.

Title

Microbial synthesis of pyrrole-2-carboxylate by Bacillus megaterium PYR2910.

Journal

Tetrahedron Lett 39:4309-4310 (1998)

Other DBs

ExplorEnz - The Enzyme Database:

4.1.1.93

IUBMB Enzyme Nomenclature:

4.1.1.93

ExPASy - ENZYME nomenclature database:

4.1.1.93

UM-BBD (Biocatalysis/Biodegradation Database):

4.1.1.93

BRENDA, the Enzyme Database:

4.1.1.93

LinkDB

DBGET integrated database retrieval system