KEGG ENZYME: 1.1.1.387

ENZYME: 1.1.1.387

Entry

EC 1.1.1.387                Enzyme

Name

L-serine 3-dehydrogenase (NAD+);
NAD+-dependent L-serine dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-serine:NAD+ 3-oxidoreductase

Reaction(IUBMB)

L-serine + NAD+ = 2-aminoacetaldehyde + CO2 + NADH + H+ (overall reaction) [RN:R10986];
(1a) L-serine + NAD+ = 2-aminomalonate semialdehyde + NADH + H+ [RN:R10985];
(1b) 2-aminomalonate semialdehyde = 2-aminoacetaldehyde + CO2 (spontaneous) [RN:R06830]

Reaction(KEGG)

R06830 R10985 R10986

Substrate

L-serine [CPD:C00065];
NAD+ [CPD:C00003];
2-aminomalonate semialdehyde [CPD:C11822]

Product

2-aminoacetaldehyde [CPD:C06735];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080];
2-aminomalonate semialdehyde [CPD:C11822]

Comment

The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase). The enzyme has only very low activity with NADP+ [cf. EC 1.1.1.276, serine 3-dehydrogenase (NADP+)].

History

EC 1.1.1.387 created 2015

Orthology

K19711

L-serine 3-dehydrogenase (NAD+)

Genes

PRE:	PCA10_42930(mmsB)

PFUW:

KF707C_13220

POJ:	PtoMrB4_24440

PLAL:

FXN65_07210(mmsB)

PAE:

PA0743

PAEV:

N297_768(mmsB)

PAEI:

N296_768(mmsB)

PAU:	PA14_54670

PAG:	PLES_46001

PAF:	PAM18_4296

PNC:	NCGM2_1469

PAEB:

NCGM1900_2036

PDK:	PADK2_21985

PSG:	G655_21655

PRP:	M062_03605

PAEP:

PA1S_22945

PAER:

PA1R_gp4235

PAEM:

U769_22455

PAEL:

T223_23470

PAES:

SCV20265_4784

PAEU:

BN889_00764

PAEG:

AI22_11210

PAEC:

M802_765(mmsB)

PAEO:

M801_767(mmsB)

SECH:

B18_15310

PCQ:	PcP3B5_38910(mmsB_2)

PMUI:

G4G71_26165(mmsB)

PNT:	G5B91_07900(mmsB)

PAP:	PSPA7_4777(mmsB1)

PPAA:

B7D75_21565(mmsB)

PDR:	H681_06605

PKC:	PKB_4189(mmsb3)

PSET:

THL1_4336

PSEJ:

HNQ25_17590(mmsB)

PWZ:	J7655_14815(mmsB)

PTW:	TUM18999_44190

PCAV:

D3880_16900(mmsB)

PSOA:

PSm6_05360

PTRL:

OU419_07020(mmsB)

PSLP:

BHQ29_15485

PBEZ:

SBP02_05755(mmsB)

PSWO:

SD196_06340(mmsB)

PMY:

Pmen_1371

PMK:

MDS_1428

PPSE:

BN5_3001(mmsB)

PALL:

UYA_07200

PKH:	JLK41_07140(mmsB)

PTY:	JWV26_17490(mmsB)

PHF:	NLY38_18285(mmsB)

PCHE:

QYM18_14560(mmsB)

PDEN:

F1C79_31765(mmsB)

PALC:

A0T30_07900

PCAM:

HNE05_11165(mmsB)

» show all

Reference

1 [PMID:22128181]

Authors

Tchigvintsev A, Singer A, Brown G, Flick R, Evdokimova E, Tan K, Gonzalez CF, Savchenko A, Yakunin AF

Title

Biochemical and structural studies of uncharacterized protein PA0743 from Pseudomonas aeruginosa revealed NAD+-dependent L-serine dehydrogenase.

Journal

J Biol Chem 287:1874-83 (2012)
DOI:10.1074/jbc.M111.294561

Sequence

[pae:PA0743]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.387

IUBMB Enzyme Nomenclature:

1.1.1.387

ExPASy - ENZYME nomenclature database:

1.1.1.387

BRENDA, the Enzyme Database:

1.1.1.387

LinkDB

DBGET integrated database retrieval system