putamen

In our case, the DaTSCAN revealed abnormal tracer uptake in the left caudate nucleus and reduced tracer uptake in the putamina (especially in the left putamen); these findings were coherent with the patient's symptoms of right-sided bradykinesia.

Alexander disease shows megalencephaly (18) and T1 hypointensity and T2/FLAIR hyperintensity in the frontal WM, caudate nuclei and anterior putamina.

Brain MRI revealed bilateral FLAIR and T1 hyperintensities of caudate nuclei, putamina and frontal lobe involving most of the anterior cingulate gyrus and superior frontal gyrus bilaterally, with restricted diffusion (Figure 1).

In neurologically symptomatic patients, T2 hyperintensity is noted in the putamina, caudate nuclei, thalami, midbrain and pons.

Earlier studies [23] using the statistical parametric mapping (SPM) software for data analysis found that compared to the cerebellum (the reference), patients with OCD showed changes in blood flow in the precuneus, left superior temporal gyrus, right superior gyri orbitales, bilateral superior frontal gyrus, and left superior parietal lobule; when compared to the whole brain region, these patients showed changes in blood perfusion in the bilateral precuneus, right cuneus, right temporal gyrus, left superior temporal gyrus, bilateral superior fontal gyrus, superior gyri orbitales, left superior parietal lobule, left frontal cingulate, bilateral putamina, right angular gyrus, and right cerebellum.