Acute
organophosphate (OP) poisoning is a significant cause of morbidity and mortality in developing countries including India.
Long QT and ST-T change associated with
organophosphate. Environ Toxicol Pharmacol.
The objective of this study was to evaluate this new bioassay technique and determine baseline susceptibility to a number of commonly used pyrethroid and
organophosphate insecticides in 2 sand fly species, P papatasi and P duboscqi (Neveu-Lemaire), which are relevant to US military operations in the Middle East and Africa.
(53.) Bird SB, Gaspari RJ, Dickson EW Early death due to severe
organophosphate poisoning is a centrally mediated process.
(7) it was found that some traditional medications contained various non-herbal substances such as alcohol, lignocaine, carbamazepine and caffeine, as well as the
organophosphate pesticides malathion and parathion.
The police said they believe
organophosphates may have been mixed into the dumplings during either production or packaging and they will investigate the food poisoning as possible attempted murder.
The reduced pseudocholinesterase concentration of 545 U/l (normal range 3 000-9 300 U/l) confirmed the clinical diagnosis of
organophosphate poisoning.
Four classes of insecticides were tested, including pyrethroids lambdacyhalothrin (diagnostic dose 0.05%), deltamethrin (4%), and permethrin (0.75%); organochlorine DDT (0.05%);
organophosphate malathion (5%); and carbamate bendiocarb (0.1%) (11).
The health effects associated with
organophosphate poisoning are a result of excess acetylcholine (ACh) present at different nerves and receptors in the body because acetylcholinesterase is blocked.
The Environment Protection Agency (EPA) has banned the use of
organophosphate but they are still being sprayed agriculturally on fruits and vegetables.
Sale of
Organophosphate insecticide is expected to dominate the global insecticides market during the forecast period
Label instructions for malathion, a workhorse
organophosphate insecticide, warn: "This pesticide is highly toxic to bees exposed to direct treatment on blooming crops or weeds.
The recent article, "Impact of environmental temperatures on resistance to
organophosphate insecticides in Aedes aegypti from Trinidad," is very interesting (1).
[2]
Organophosphate induced delayed polyneuropathy (OPIDP), a sensory-motor distal axonopathy, usually occurs 1-4 weeks after single or short-term exposures and it may be progressive and severe.
