The patients in the special intervention group received hydrochlorothiazide or chlorthatidone, with reserpine,
methyldopa, or propranolol added to control blood pressure as necessary.
There will be no significant differences in the occurrence or type of side effects between treatment groups (patients receiving [beta]-blockers,
methyldopa, thiazide diuretics, or angiotensin-converting enzyme inhibitors will not significantly differ in reported symptoms of depression and physical discomfort over time).
Subjects whose blood pressure was not adequately controlled at the first follow-up visit were transferred to another treatment group, apparently almost all to the hydrochlorothiazide-triamterene group ([n = 34], compared with metroprolol [n = 17], captopril [n = 13] and
methyldopa [n = 101).
Methyldopa is the oldest and safest drug during pregnancy.
A 250 milligrammes
methyldopa tablet, was being sold for Rs840 instead of its approved price of Rs638.
Treatment was started at the time of diagnosis in both the groups either with nifedipine,
methyldopa or labetalol and were followed up with blood pressure check-up, clinical and symptomatic assessment with routine tests including complete blood count, urine analysis, renal and liver function tests, random blood sugar, serum electrolytes and 24-hour urine protein.
Objective: To compare the effects of labetalol and
methyldopa on mean diastolic blood pressure in patients with pre-eclampsia.
The drug,
methyldopa, has been used for over 50 years to treat high blood pressure in pregnant women and children.
Because 1g/day of
methyldopa was administered for two weeks before admission, she was asymptomatic at the time of admission, and she had a persistent blood pressure of 160/120 mmHg and edema in the lower limbs 4+/4+.
The main drugs that are known to cause this include minocycline, alpha
methyldopa, nitrofurantoin, diclofenac, hydralazine, statins, and anti-TNF agents [1].
Stock solutions of Ldopa, dopamine,
methyldopa, benserazide, and carbidopa were prepared by dissolving 100 mg of each drug in 100 mL of 0.1 N hydrochloric acid individually.
Among 11 patients with risk factors in the antenatal period, 4 (36.4%) had persistent proteinuria and haematuria, and 2 (18.2%) had gestational hypertension, well controlled on
methyldopa. Two (18.2%) patients diagnosed with mild to moderate pre-eclampsia on two different types of antihypertensive agents were being treated as outpatients (Table 2) with poor blood pressure control.
