8th edition AJCC/UICC staging of cancers of the esophagus and
esophagogastric junction: application to clinical practice.
Diagnosis and treatment of non-metastatic
esophagogastric junction adenocarcinoma: what are the current options?
KEY WORDS: Adenocarcinoma of
esophagogastric junction, Gastric tube, Quality of life, EORTC QLQ-C30, EORTC QLQ-STO22.
Previously, it was left to the judgment of the physicians involved to classify the tumors located at the
esophagogastric junction as esophageal or gastric.
Becker et al., "Prediction of response to preoperative chemotherapy in adenocarcinomas of the
esophagogastric junction by metabolic imaging," Journal of Clinical Oncology, vol.
Data Source: An observational study of
esophagogastric junction adenocarcinoma involving gene expression profile analysis in 28 patients and immunohistochemical and outcome analysis in 154 patients.
The Merindino procedure following pre-operative imatinib mesylate for locally advanced gastrointestinal stromal tumor of the
esophagogastric junction. World J Surg Oncol.
Whiteman, head of the Cancer Control Laboratory at the Queensland (Australia) Institute of Medical Research looked at 794 Australian patients aged 18-79 years with a primary invasive cancer of the esophagus or
esophagogastric junction.
The Medical Subject Headings developed by the United States National Library of Medicine (NLM, 2006) defines cardia as "that part of the stomach close to the opening from esophagus into the stomach (cardiac orifice), the
esophagogastric junction. Cardia is characterized by the lack of acid-forming cells (gastric parietal cells)".
Evaluation of the
esophagogastric junction revealed a small sliding hiatal hernia and Los Angeles Classification grade A erosive esophagitis (figure, B).
According to clinical trial data and consensus statements from the Fourth International Conference on Capsule Endoscopy, esophageal capsule endoscopy can be used to evaluate the
esophagogastric junction and rule out Barrett's esophagus in patients with chronic reflux.
Merck announced the first presentation of results from KEYNOTE-181, a Phase 3 trial investigating KEYTRUDA, Merck's anti-PD-1 therapy, as monotherapy for the second-line treatment of advanced or metastatic esophageal or
esophagogastric junction carcinoma.
(12-19) Within a similar time period, the International Mesothelioma Interest Group, the International Thymic Malignancy Interest Group (ITMIG), and the Worldwide Esophageal Cancer Collaboration, in conjunction with the IASLC, developed proposals, assembled databases, and recommended tumor, node, metastasis (TNM) system categories for mesothelioma (N = 3519), (20-23) thymic epithelial tumors (N = 10 808), (24-27) and esophageal/
esophagogastric junction (EGJ) cancers.
Is this a retroflexed view of the endoscope entering the stomach at the
esophagogastric junction? Is there also an image of the gastric outlet obstructed by the polypoid tumor?
