T-cells protect our bodies against disease by eliminating cancerous cells, and those infected with viruses and bacteria. However, because T-cells have evolved not to attack our own tissue in order limit autoimmune disease, T-cell responses to cancer, which develops from our own tissue, are poor. In order to resolve this problem, we have developed strategies to build T-cells with an artificially improved ability to target and eliminate cancer cells. By generating artificial T-cells which have been optimised to respond to disease, we aim to provide a generalised method that can be used to treat many forms of cancer.