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. 2025 Apr;35(4):231-232.
doi: 10.1038/s41422-025-01083-x.

Raptin, a novel brain hormone links sleep health to body weight gain

Leonie Cabot  1   2 , Henning Fenselau  3   4   5
Affiliations

Raptin, a novel brain hormone links sleep health to body weight gain

Leonie Cabot et al. Cell Res. 2025 Apr.
No abstract available

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Schematic representation of raptin action.
In individuals with balanced sleep (green, left), raptin levels peak during the sleep phase. SCN neuron projections regulate raptin secretion from PVH neurons that express RCN2. Raptin acts locally on PVH neurons and is secreted into the bloodstream to decrease food intake and body weight gain. In individuals with sleep disruption (red, right), raptin secretion is reduced, particularly during the sleep phase. Reduced raptin levels contribute to increased food intake and weight gain in response to sleep irregularities. Created with BioRender.com.
See this image and copyright information in PMC

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