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. 2019 Apr;45(4):664-668.
doi: 10.1080/03639045.2019.1569034. Epub 2019 Feb 11.

Bioanalytical method development and its application to pharmacokinetics studies on Simvastatin in the presence of piperine and two of its synthetic derivatives

Pratibha Auti  1 , Satish Gabhe  1 , Kakasaheb Mahadik  1
Affiliations

Bioanalytical method development and its application to pharmacokinetics studies on Simvastatin in the presence of piperine and two of its synthetic derivatives

Pratibha Auti et al. Drug Dev Ind Pharm. 2019 Apr.

Abstract

Piperine has been widely used as a bioenhancer. Simvastatin belongs to a group of medicines known as statins. It acts by inhibiting HMG CoA reductase and acts primarily as a hypolipidemic agent. In this study some derivatives of Piperine were synthesized. They were studied for their bioenhencing effect (10 mg kg-1) and this effect was compared with that of Piperine. The pharmacokinectic profile of Simvastatin alone and in combination with Piperine and Piperine derivatives were investigated by validated HPLC method as per USFDA guidelines. It was seen that the two synthesized derivatives of Piperine significantly improved the bioavailability of Simvastatin in Wistar rats. The 5-(benzo) [1,3]dioxol-5-yl)-N-(pyridin-4-yl)penta-2,4-dienamide was better amongst the synthesized in increasing the bioavailability of Simvastatin in Wistar rat.

Keywords: AUC; HPLC; Simvastatin; bioenhancing effect; pharmacokinetics; piperine.

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