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. 2014 Aug 13;16(2):150-152.
doi: 10.1016/j.chom.2014.07.013.

How a virus blocks a cellular emergency access lane to the nucleus, STAT!

Matthew D Daugherty  1 , Harmit S Malik  2
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How a virus blocks a cellular emergency access lane to the nucleus, STAT!

Matthew D Daugherty et al. Cell Host Microbe. .
Free article

Abstract

Early in viral infection, the STAT1 transcription factor is rapidly transported into the nucleus using a nonconventional import mechanism to establish an antiviral state. In this issue, Xu et al. (2014) show how the Ebola virus VP24 protein precisely blocks specialized STAT1 import while leaving other cellular import processes intact.

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