Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Aug;62(8):384-8.
doi: 10.1055/s-0032-1314849. Epub 2012 Jun 29.

Effect of piperine on antihyperglycemic activity and pharmacokinetic profile of nateglinide

V Sama  1 , M Nadipelli, P Yenumula, M R Bommineni, R Mullangi
Affiliations

Effect of piperine on antihyperglycemic activity and pharmacokinetic profile of nateglinide

V Sama et al. Arzneimittelforschung. 2012 Aug.

Abstract

Piperine (CAS no: 94-62-2), an alkaloid obtained from Piper nigrum and P. longum is a known inhibitor of various enzymes (CYP isozymes) responsible for biotransformation of drugs. By inhibiting the metabolism of drugs, piperine improves the bioavailability of drugs. In the present study piperine (10 mg/kg) significantly increased the dose-dependent anti-hyperglycemic activity of nateglinide (CAS no: 105816-04-4) as evaluated by glucose challenged and alloxan-induced diabetic models, when it was administered with nateglinide. Nateglinide plasma concentrations were also increased, when administered with piperine. The synergistic anti-hyperglycemic activity of nateglinide when administered with piperine can be attributed to increased plasma concentration of nateglinide. The results of this study demonstrate that piperine could be used as a potential bioenhancer along with nateglinide.

PubMed Disclaimer

MeSH terms

LinkOut - more resources