Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Aug;4(8):685-7.
doi: 10.1002/emmm.201200246. Epub 2012 May 15.

Telomerase gene therapy: a novel approach to combat aging

Virginia Boccardi  1 , Utz Herbig
Affiliations
Comment

Telomerase gene therapy: a novel approach to combat aging

Virginia Boccardi et al. EMBO Mol Med. 2012 Aug.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. Promoting healthspan in mice using a telomerase gene therapy
Delivery of telomerase (TERT) using rAAV suppresses aging associated telomere erosion and extends short telomeres in a variety of mouse tissues. Consequently, animals display improved healthspan and extended lifespan.
See this image and copyright information in PMC

Comment on

References

    1. Artandi SE, DePinho RA. Telomeres and telomerase in cancer. Carcinogenesis. 2010;31:9–18. - PMC - PubMed
    1. Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 2011;479:232–236. - PMC - PubMed
    1. Bernardes de Jesus B, Vera E, Schneeberger K, Tejera AM, Ayuso E, Bosch F, Blasco MA. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med. 2012 DOI . - DOI - PMC - PubMed
    1. Flores I, Canela A, Vera E, Tejera A, Cotsarelis G, Blasco MA. The longest telomeres: a general signature of adult stem cell compartments. Genes Dev. 2008;22:654–667. - PMC - PubMed
    1. Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, Kaplunov JM, Bucci G, Dobreva M, Matti V, Beausejour CM, et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol. 2012 DOI: . - DOI - PMC - PubMed