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Review
. 2006 Jul;6(7):739-46.
doi: 10.2174/138955706777698688.

Structural and functional properties of NAD kinase, a key enzyme in NADP biosynthesis

Giulio Magni  1 , Giuseppe Orsomando, Nadia Raffaelli
Affiliations
Review

Structural and functional properties of NAD kinase, a key enzyme in NADP biosynthesis

Giulio Magni et al. Mini Rev Med Chem. 2006 Jul.

Abstract

NAD kinase is an essential enzyme, which plays a key role in cellular energy and signal transduction systems. In this report, the recent studies on the features of bacterial and human NAD kinases are summarized. They include detailed kinetic and structural analyses and highlight important differences, which could be exploited for the design of novel selective antimicrobial drugs.

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