erythropoietin

(redirected from Eprex)
Also found in: Dictionary, Thesaurus, Encyclopedia.

erythropoietin

 [ĕ-rith″ro-poi´ĕ-tin]
a glycoprotein hormone secreted by the kidney in the adult and by the liver in the fetus, which acts on stem cells of the bone marrow to stimulate red blood cell production (erythropoiesis).
recombinant human erythropoietin epoetin.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

e·ryth·ro·poi·e·tin (EPO),

(ĕ-rith'rō-poy'ĕ-tin), [MIM*133170]
A protein containing sialic acid that enhances erythropoiesis by stimulating formation of proerythroblasts and release of reticulocytes from bone marrow; it is formed by the kidney and liver, and possibly by other tissues, and can be detected in human plasma and urine.
Synonym(s): erythropoietic hormone (2) , hematopoietin, hemopoietin
Farlex Partner Medical Dictionary © Farlex 2012

erythropoietin

(ĭ-rĭth′rō-poi-ē′tĭn)
n.
1. A glycoprotein hormone that stimulates the production of red blood cells by stem cells in bone marrow. Produced mainly by the kidneys, it is released in response to decreased levels of oxygen in body tissue.
2. Epoetin alfa.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

EPO

A gene on chromosome 7q22 that encodes erythropoietin, a secreted, glycosylated cytokine found in the plasma, which regulates red cell production by promoting erythroid differentiation and initiating haemoglobin synthesis. Erythropoietin plays a neuroprotective role in response to brain injury and is antiapoptotic.

Molecular pathology
Genetic variability of EPO has been linked to microvascular complications of diabetes type 2, including diabetic retinopathy, nephropathy leading to end-stage renal disease, and neuropathy
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

erythropoietin

EPO Physiology A 46 kD glycoprotein colony-stimulating factor produced predominantly by cells adjacent to the proximal renal tubules in response to signals from an oxygen-sensitive substances in the kidneys–eg, heme Adverse effects Chest pain, swelling, tachycardia, headache, HTN; erythropoietin–EP binds to receptors in erythroid precursors that mature into RBCs; EP is ↑ by hypoxia or by ectopic production from tumors–eg, cerebellar hemangioblastoma, hepatoma, pheochromocytoma, uterine leiomyoma, and renal cell carcinoma; it may not be ↑ in anemic premature infants, and is ↓ in 2º anemia, chronic inflammation, P vera, and certain CAs and may be useful in myeloma-related anemia; EP therapy is indicated for HIV-related anemia, anemia of renal failure and prematurity; it ↑ number of units of autologous RBCs that may be donated before surgery, for ↑ number of units that may be phlebotomized in Pts with hemochromatosis and to ↑ units that may be drawn from a person with a rare blood type
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

e·ryth·ro·poi·e·tin

(ĕ-rith'rō-poy'ĕ-tin)
A protein that enhances erythropoiesis by stimulating formation of proerythroblasts and releasing reticulocytes from bone marrow; secreted mainly by the kidney and possibly by other tissues.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Erythropoietin

A hormone produced by the kidneys that stimulates the production of red blood cells by bone marrow.
Mentioned in: Dialysis, Kidney
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
DISCUSSION: In the present study, target hemoglobin levels (11 to 12 gms) were achieved in 84% in 42 out of 50 patients with the 10000 units of EPO (Eprex) subcutaneously once in week in 28 weeks of duration of treatment which is comparable with Robert Benz et al study in which target hemoglobin achieved in 88.1% in 59 out of 67 patients.
Correction of anaemia with erythropoietin in CKD/ESRD patients
Doses of Eprex were administered via IV, either three (Group A) or two times per week (Group B) and these dosages were revised monthly based on target haematologic parameters (Barbara et al., 2006).
Improved haemoglobin levels with reduced frequency of administration of epoetin alfa
J&J reported the week prior that early data showed Eprex patients in the German study died more frequently than placebo patients, and said it was doing additional analyses to better understand the findings.
US health officials said on Friday they were reviewing a higher rate of deaths among patients treated with a Johnson & Johnson (New Brunswick NJ) anemia drug in a German study of stroke patients
"This issue is largely due to one product, Eprex. Physicians in the United States need a heightened awareness of the situation, but it's currently not a cause for concern," said Dr.
Epoetin alfa product tied to pure red cell aplasia. (Eprex not Sold in United States)
Intense investigation revealed Eprex had a different immunogenicity profile than Epogen, and patients had developed antibodies to Eprex.
Tipping point: biosimilars, emerging markets, and public-private engagement to promote global health
Its sales of Procrit and a similar drug, Eprex, dropped 14% worldwide in the second quarter to $652 million, and fell 23% in the United States to $346 million.
Amgen told to change drug labels
Novartis AG's Sandoz unit, the world's second-largest maker of generic drugs, became the first company to win approval for a biological copy of Johnson & Johnson's (New Brunswick NJ) Eprex anemia treatment, allowing it to offer cheaper versions to Europeans.
Novartis AG's Sandoz unit, the world's second-largest maker of generic drugs, became the first company to win approval for a biological copy of Johnson & Johnson's (New Brunswick NJ) Eprex anemia treatment, allowing it to offer cheaper versions to Europeans
The FDA considers Eprex and NeoRecormon to be in the same class as the three erythropoietin products approved in the United States: erythropoietin alfa (Epogen) and darbepoetin alfa (Aranesp), both by" Amgen: and Procrit, by Ortho Biotech Products.
Erythropoietin safety at issue in ongoing studies; European data raise concerns
In most patients, ESAs must be dosed frequently to maintain efficacy (Aranesp Product Information, 2008; Eprex Product Information, 2008; NeoRecormon Product Information, 2008).
A survey of Australian patient preferences regarding subcutaneous erythropoiesis-stimulating agents
* A new Sanyo Scientific Biomedical medication fridge that is connected to the clinic's security system has been purchased for Eprex and Aranesp.
Ontario Region (Jane Alfarero)
A less widely heralded event, but one with potentially greater implications, is the approval in August 2007 of Sandoz' follow-on version of erythropoietin-[alpha], marketed by Amgen as Epogen and by Ortho Biotech as Eprex. Erythropoietin products are widely used in the treatment of anaemia, secondary to chronic renal failure or chemotherapy.
Biogenerics 2007: how far have we come?
Sandoz' generic is a version of the drug that Johnson & Johnson sells in Europe under the Eprex banner.
Biosimilar drug wins approval in European Union

Medical browser ?
Full browser ?