May 26, 2026

Requiring code sharing to strengthen transparency and trust in research

Recognizing that code is as essential a research artifact as the data it analyzes, this Editorial outlines how PLOS Medicine is strengthening its code sharing policy to further ensure reproducibility and trust in the scientific record.

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05/13/2026

Research Article

Contribution of nosocomial transmission to Klebsiella pneumoniae neonatal sepsis in Africa and South Asia: An observational study of infection clusters inferred from pathogen genomics and temporal data

In an observational study, Erkison Odih and colleagues use pathogen sequencing to show that a high rate of nosocomial transmission accounts for invasive Klebsiella pneumoniae disease in neonatal care units in 13 countries in Africa and Asia.

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Contribution of nosocomial transmission to Klebsiella pneumoniae neonatal sepsis in Africa and South Asia: An observational study of infection clusters inferred from pathogen genomics and temporal data

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Browse Issues 2004 – 2026

05/14/2026

Research Article

Antibody fine specificity correlates with protection from malaria for the RTS,S vaccine in young African children: A post hoc analysis of a phase IIb randomised controlled trial

In a post hoc analysis of antibody responses elicited by the RTS, S/AS01 malaria vaccine, Alessia Hysa and colleagues identify candidate antibody specificities that associate with protection against malaria in children.

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Antibody fine specificity correlates with protection from malaria for the RTS,S vaccine in young African children: A post hoc analysis of a phase IIb randomised controlled trial

05/21/2026

Perspective

U = U for all: Advancing equity in HIV prevention

Suppression of HIV with antiretrovirals eliminates HIV transmission risk, summarized as Undetectable = Untransmittable (U=U). However, U=U literacy remains unevenly understood and shared, and stigmas persist. In this Perspective, Thiago Torres and Paula Luz outline what is needed to improve equity and accuracy in global awareness and education of U=U.

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U = U for all: Advancing equity in HIV prevention

05/06/2026

Research Article

Point-of-care early infant HIV diagnosis at birth in a pragmatic cluster-randomized trial in Mozambique and Tanzania: A comparative cost and cost-effectiveness study

Kira Elsbernd and colleagues analyze the cost and cost effectiveness of adding HIV diagnosis at birth to routine practice to promote earlier initiation of antiretroviral therapy in primary healthcare facilities in Mozambique and Tanzania.

Image credit: Fusz Photography, Pexels

05/12/2026

Research Article

Social contact patterns in the United Kingdom following the COVID-19 pandemic: The Reconnect cross-sectional survey

In a cross-sectional survey, Lucy Goodfellow and colleagues collect information from over 13,000 people on demographics and their social contacts after the COVID-19 pandemic in the UK.

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05/06/2026

Research Article

Pathways of emergency care for severely ill children in Nigerian and Ugandan hospitals: A process mapping study

In a qualitative study, Rami Subhi and colleagues aimed to describe the organisation and patient flow of facilities in Nigeria and Uganda, using process mapping. The findings are intended to inform future interventions to improve pediatric emergency care.

Image credit: Etienne Girardet, Unsplash

05/11/2026

Perspective

Connected or chained by social media? Child and adolescent mental health in a digital era

Silja Kosola outlines how social media disproportionately harms child and adolescent mental health, and argues that stricter age limits and greater accountability of social media companies are needed.

Image credit: Karsten Winegeart, Unsplash

05/15/2026

Research Article

Spatial transcriptomic-metabolic features of tumor foci and tumor capsule in microvascular invasion with hepatocellular carcinoma: A spatial multi-omics study

By Zhi-Hui Luo, Na Wang, Jingwei Zhao and colleagues.

Image credit: Figure 2b, panel P1

05/05/2026

Research Article

Multimorbidity, health service use, and health insurance by socioeconomic groups in 31 countries: A multi-cohort study

Yanshang Wang and colleagues investigate the relationship between multimorbidity, health service use and health insurance.

Image credit: TBIT, Pixabay

05/13/2026

Perspective

On the evolution of the company we keep: Implications for infectious disease modeling

In this Perspective, Joël Mossong discusses the importance of understanding social contacts and how they evolve for infectious disease modeling.

Image credit: Priscilla Du Preez, Unsplash

Bacterial Antimicrobial Resistance

Antimicrobial Resistance: Addressing a Global Threat to Humanity

In this Editorial, Guest Editors Timothy R. Walsh, Ana C. Gales, Ramanan Laxminarayan, and our PLOS Medicine Editor Philippa C. Dodd discuss the Special Issue dedicated to Antimicrobial resistance and emphasize the urgent threat of AMR.
Global incidence in hospital-associated infections resistant to antibiotics: An analysis of point prevalence surveys from 99 countries

Ruchita Balasubramanian and colleagues, estimate the incidence of hospital-associated infections resistant to antibiotics in 195 countries using point prevalence survey data.
Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)

James Neal Russell and colleagues explore antibiotic use and mortality prediction in hospitalised neonates and infants with sepsis.
Antimicrobial resistance: Strengthening surveillance for public health action

Silvia Bertagnolio, Amitabh Bipin Suthar, Olga Tosas and Kitty Van Weezenbeek discuss surveillance of antimicrobial resistance, the existing limitations and the implications this has on accurate determination of incidence.

PLOS Medicine Collections

COVID-19 Pandemic and Global Mental Health

In this Special Issue, we present a fascinating array of research papers providing insights into various facets of mental health during the pandemic.
Bacterial Antimicrobial Resistance: Surveillance and Prevention

This collection of research articles highlights the multi-faceted challenges imposed by drug-resistant bacteria, the consequences for health and economics, and interventions that could lessen the burden.
Early Detection and Minimal Residual Disease

In this Collection, PLOS Medicine presents high-quality translational research and clinical studies on advances in early cancer detection.
Global Child Health: From Birth to Adolescence and Beyond

This Special Issue brings together the latest research on child and adolescent health, including strategies to monitor and combat child mortality from birth through adolescence, and environmental impacts on child health and mortality.
Maternal and Child Health & Nutrition

This 2019 Special Issue highlights the importance of nutrition for maternal and child health.

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