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Haloperidol

From Wikipedia
Haloperidol
type of chemical entity
Subclass ofalcohols, heterocyclic compound Edit
Part ofresponse to haloperidol, cellular response to haloperidol Edit
Get useMedication Edit
Chemical formulaC₂₁H₂₃ClFNO₂ Edit
Canonical SMILESC1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F Edit
Active ingredient inHaldol Edit
World Health Organisation international non-proprietary namehaloperidol Edit
Legal status (medicine)boxed warning Edit
Pregnancy categoryAustralian pregnancy category C, US pregnancy category C Edit
LiverTox likelihood scoreLiverTox toxicity likelihood category B Edit
Get characteristicbitterness Edit
MCN code2933.39.15 Edit

Haloperidol, dem sell under de brand name Haldol among odas, be a typical antipsychotic medication.[1] Haloperidol be used insyd de treatment of schizophrenia, tics insyd Tourette syndrome, mania insyd bipolar disorder, delirium, agitation, acute psychosis, den hallucinations from alcohol withdrawal.[1][2][3] E fi be used by mouth anaa injection into a muscle anaa a vein.[1] Haloperidol typically dey work within 30 to 60 minutes.[1] A long-acting formulation fi be used as an injection every four weeks for people plus schizophrenia anaa related illnesses, wey either forget anaa refuse to take de medication by mouth.[1]

Haloperidol fi result in movement disorders such as tardive dyskinesia, den akathisia, both of wich fi be permanent.[4] Neuroleptic malignant syndrome den QT interval prolongation fi occur, de latter particularly plus IV administration.[4] Insyd older people plus psychosis secof dementia e dey result in an increased risk of death.[4] Wen dem take am during pregnancy e fi result in problems insyd de infant.[4][5] E for no be be used by people plus Parkinson's disease.[4]

Na dem discover haloperidol insyd 1958 by de team of Paul Janssen,[6] dem prepare as part of a structure-activity relationship investigation into analogs of pethidine (meperidine).[7] E dey on de World Health Organization's List of Essential Medicines.[8] E be de most commonly used typical antipsychotic.[9] Insyd 2020, na e be de 303rd most commonly prescribed medication insyd de United States, plus more dan 1 million prescriptions.[10]

References

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  1. 1 2 3 4 5 "Haloperidol". The American Society of Health-System Pharmacists. Archived from the original on 2 January 2015. Retrieved 2 January 2015.
  2. ↑ Schuckit MA (November 2014). "Recognition and management of withdrawal delirium (delirium tremens)". The New England Journal of Medicine. 371 (22): 2109–2113. doi:10.1056/NEJMra1407298. PMID 25427113. S2CID 205116954.
  3. ↑ Plosker GL (July 2012). "Quetiapine: a pharmacoeconomic review of its use in bipolar disorder". PharmacoEconomics. 30 (7): 611–631. doi:10.2165/11208500-000000000-00000. PMID 22559293.
  4. 1 2 3 4 5 "Haloperidol". The American Society of Health-System Pharmacists. Archived from the original on 2 January 2015. Retrieved 2 January 2015.
  5. ↑ "Prescribing medicines in pregnancy database". Australian Government. 3 March 2014. Archived from the original on 8 April 2014. Retrieved 2 January 2015.
  6. ↑ Sneader W (2005). Drug discovery: a history (Rev. and updated ed.). Chichester: Wiley. p. 124. ISBN 978-0-471-89979-2. Archived from the original on 8 December 2015.
  7. ↑ Ravina E (2011). The evolution of drug discovery: from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: Wiley-VCH. p. 62. ISBN 978-3-527-32669-3. Archived from the original on 8 December 2015.
  8. ↑ World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. 2021. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  9. ↑ Stevens A (2004). Health care needs assessment: the epidemiologically based needs assessment reviews (2nd ed.). Abingdon: Radcliffe Medical. p. 202. ISBN 978-1-85775-892-4. Archived from the original on 8 December 2015.
  10. ↑ "Haloperidol - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
[edit | edit source]
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