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A nodular lesion, termed the Aschoff body, may be identifiable microscopically within the myocardium (mainly of the left atrium) or in the pericardium.
(65) Some of the macrophages in an Aschoff body may become multinucleated giant cells.
Delay in manifestations of ARF following infection and the presence of infiltrates of T-helper lymphocytes and macrophages in acute rheumatic valvulitis and B cells in Aschoff body suggest an important role of the immune system in the pathogenesis of this disease.
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