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NPAS1

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neuronal PAS domain protein 1
Identifiers
SymbolNPAS1
NCBI gene4861
HGNC7894
OMIM603346
RefSeqNM_002517
UniProtQ99742
Other data
LocusChr. 19 q13.2-13.3
Search for
StructuresSwiss-model
DomainsInterPro

NPAS1 is a basic helix-loop-helix transcription factor.[1][2] Npas1 is expressed in the developing forebrain in neuronal precursors of GABAergic projection neurons in the globus pallidus and basal forebrain as well as cortical and hippocampal interneurons[3][4][5][6]. Experiments in mice have linked neurons expressing Npas1 in the external globus pallidus to motor control[7][8] and those in the basal forebrain to sleep-wake control[9] and stress responsiveness[10]. Knockout and gene expression experiments have linked Npas1 to the control of behaviors and genes related to neuropsychiatric disorders [11][12]

See also

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References

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  1. ^ Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, Richardson J, Russell DW, McKnight SL (January 1997). "Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system". Proc. Natl. Acad. Sci. U.S.A. 94 (2): 713–8. Bibcode:1997PNAS...94..713Z. doi:10.1073/pnas.94.2.713. PMC 19579. PMID 9012850.
  2. ^ Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA (March 1997). "Characterization of a subset of the basic helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway". J. Biol. Chem. 272 (13): 8581–93. doi:10.1074/jbc.272.13.8581. PMID 9079689.
  3. ^ Cobos, Inma; Long, Jason E.; Thwin, Myo T.; Rubenstein, John L. (2006-07-01). "Cellular Patterns of Transcription Factor Expression in Developing Cortical Interneurons". Cerebral Cortex. 16 (suppl_1): i82–i88. doi:10.1093/cercor/bhk003. ISSN 1460-2199.
  4. ^ Flandin, Pierre; Kimura, Shioko; Rubenstein, John L. R. (2010-02-24). "The Progenitor Zone of the Ventral Medial Ganglionic Eminence Requires Nkx2-1 to Generate Most of the Globus Pallidus But Few Neocortical Interneurons". The Journal of Neuroscience. 30 (8): 2812–2823. doi:10.1523/JNEUROSCI.4228-09.2010. ISSN 0270-6474. PMC 2865856.
  5. ^ Nóbrega-Pereira, Sandrina; Gelman, Diego; Bartolini, Giorgia; Pla, Ramón; Pierani, Alessandra; Marín, Oscar (2010-02-24). "Origin and Molecular Specification of Globus Pallidus Neurons". The Journal of Neuroscience. 30 (8): 2824–2834. doi:10.1523/JNEUROSCI.4023-09.2010. ISSN 0270-6474. PMC 6633933.
  6. ^ Stanco, Amelia; Pla, Ramón; Vogt, Daniel; Chen, Yiran; Mandal, Shyamali; Walker, Jamie; Hunt, Robert; Lindtner, Susan; Erdman, Carolyn; Pieper, Andrew; Hamilton, Steven; Xu, Duan; Baraban, Scott; Rubenstein, John (3 Dec 2014). "NPAS1 Represses the Generation of Specific Subtypes of Cortical Interneurons". Neuron. 84 (5): 940–953. doi:10.1016/j.neuron.2014.10.040. PMC 4258152. PMID 25467980.
  7. ^ Hernandez, V. M.; Hegeman, D. J.; Cui, Q.; Kelver, D. A.; Fiske, M. P.; Glajch, K. E.; Pitt, J. E.; Huang, T. Y.; Justice, N. J.; Chan, C. S. (2015-08-26). "Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus". Journal of Neuroscience. 35 (34): 11830–11847. doi:10.1523/JNEUROSCI.4672-14.2015. ISSN 0270-6474.
  8. ^ Pamukcu, Arin; Cui, Qiaoling; Xenias, Harry S.; Berceau, Brianna L.; Augustine, Elizabeth C.; Fan, Isabel; Chalasani, Saivasudha; Hantman, Adam W.; Lerner, Talia N.; Boca, Simina M.; Chan, C. Savio (2020-10-07). "Parvalbumin + and Npas1 + Pallidal Neurons Have Distinct Circuit Topology and Function". The Journal of Neuroscience. 40 (41): 7855–7876. doi:10.1523/JNEUROSCI.0361-20.2020. ISSN 0270-6474. PMC 7548687.
  9. ^ Troppoli, Timothy A.; Yang, Chun; Katsuki, Fumi; Uygun, David S.; Lin, Ilyan; Aguilar, David D.; Spratt, Tristan; Basheer, Radhika; McNally, James M.; Savio Chan, C.; McKenna, James T.; Brown, Ritchie E. (2024-05-21). "Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in the basal forebrain". Proceedings of the National Academy of Sciences. 121 (21). doi:10.1073/pnas.2321410121. ISSN 0027-8424. PMC 11127008. PMID 38748575.
  10. ^ Morais-Silva, Gessynger; Campbell, Rianne R.; Nam, Hyungwoo; Basu, Mahashweta; Pagliusi, Marco; Fox, Megan E.; Chan, C. Savio; Iñiguez, Sergio D.; Ament, Seth; Cramer, Nathan; Marin, Marcelo Tadeu; Lobo, Mary Kay (2023-01-18). "Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons". The Journal of Neuroscience. 43 (3): 405–418. doi:10.1523/JNEUROSCI.0971-22.2022. ISSN 0270-6474.
  11. ^ Erbel-Sieler, Claudia; Dudley, Carol; Zhou, Yudong; Wu, Xinle; Estill, Sandi Jo; Han, Tina; Diaz-Arrastia, Ramon; Brunskill, Eric W.; Potter, S. Steven; McKnight, Steven L. (2004-09-14). "Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors". Proceedings of the National Academy of Sciences. 101 (37): 13648–13653. doi:10.1073/pnas.0405310101. ISSN 0027-8424. PMC 518807. PMID 15347806.
  12. ^ Michaelson, Jacob J.; Shin, Min-Kyoo; Koh, Jin-Young; Brueggeman, Leo; Zhang, Angela; Katzman, Aaron; McDaniel, Latisha; Fang, Mimi; Pufall, Miles; Pieper, Andrew A. (2017). "Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes". Biological Psychiatry. 82 (3): 213–223. doi:10.1016/j.biopsych.2017.03.021. PMC 6901278. PMID 28499489.
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