Abstract
CCL2/Monocyte Chemoattractant Protein (MCP)-1 and other chemokines sharing a similar sequence, including CCL8/MCP-2, are involved in neurodegeneration. A few Single Nucleotide Polymorphisms (SNPs) have been reported in CCL8/MCP-2, all of which are located in the same linkage block. One of them (rs1163763) leads to an aminoacidic substitution, implying a potential impact on the function of the protein. rs1133763 was tested for association in 219 patients with Alzheimer’s disease (AD) and 209 with Frontotemporal Lobar Degeneration (FTLD) as compared with 231 age-matched controls. The distribution of CCL8/MCP-2 rs1133763 was not significantly different among patients with AD or FTLD and controls, even stratifying according to gender. CCL8/MCP rs1133763 SNP, or other variants in linkage disequilibrium with this variant, likely do not influence the susceptibility to AD or FTLD in Caucasians.
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Acknowledgments
This work was supported by grants from Monzino Foundation, IRCCS Ospedale Maggiore Policlinico, Associazione per la Ricerca sulle Demenze (ARD), grants PS-NEURO ex 56/05/4 and PS-NEURO ex 56/05/11, Italian Ministry of Health, and Ing. Cesare Cusan.
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Villa, C., Venturelli, E., Fenoglio, C. et al. CCL8/MCP-2 association analysis in patients with Alzheimer’s disease and frontotemporal lobar degeneration. J Neurol 256, 1379–1381 (2009). https://doi.org/10.1007/s00415-009-5138-y
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DOI: https://doi.org/10.1007/s00415-009-5138-y