Semaglutide

Tɛmplet:Infobox drug/title
Names
Trade names	Ozempic, Rybelsus, Wegovy, others
Clinical data
Drug class	GLP-1 agonist
WHO AWaRe	Script error: No such module "WDfetch".
Pregnancy; category	Tɛmplet:Infobox drug/pregnancy category
Routes of; use	Subcutaneous, by mouth
Duration of action	63.6 h
External links
AHFS/Drugs.com	Tɛmplet:Drugs.com
MedlinePlus	a618008
Legal
[[Regulation of therapeutic goods \|Tɛmplet:Engvar data]]	Tɛmplet:Infobox drug/licence
Legal status	Tɛmplet:Infobox drug/legal status
Pharmacokinetics
Bioavailability	89%
Metabolism	Proteolysis
Elimination half-life	1 week
Excretion	Urine and faeces
Identifiers
CAS Number	Tɛmplet:Infobox drug/formatCASnumber; Tɛmplet:Infobox drug/formatCASnumber;
PubChem CID	Tɛmplet:Infobox drug/formatPubChemCID; Tɛmplet:Infobox drug/formatPubChemCID;
PubChem SID	Tɛmplet:Infobox drug/formatPubChemSID; Tɛmplet:Infobox drug/formatPubChemSID;
IUPHAR/BPS	Tɛmplet:Infobox drug/formatIUPHARBPS; Tɛmplet:Infobox drug/formatIUPHARBPS;
DrugBank	Tɛmplet:Infobox drug/formatDrugBank; Tɛmplet:Infobox drug/formatDrugBank;
ChemSpider	Tɛmplet:Infobox drug/formatChemSpider; Tɛmplet:Infobox drug/formatChemSpider;
UNII	Tɛmplet:Infobox drug/formatUNII; Tɛmplet:Infobox drug/formatUNII;
KEGG	Tɛmplet:Infobox drug/formatKEGG; Tɛmplet:Infobox drug/formatKEGG;
ChEBI	Tɛmplet:Infobox drug/formatChEBI; Tɛmplet:Infobox drug/formatChEBI;
ChEMBL	Tɛmplet:Infobox drug/formatChEMBL; Tɛmplet:Infobox drug/formatChEMBL;
NIAID ChemDB	Tɛmplet:Infobox drug/formatChemDBNIAID; Tɛmplet:Infobox drug/formatChemDBNIAID;
PDB ligand	Tɛmplet:Infobox drug/formatPDBligand; Tɛmplet:Infobox drug/formatPDBligand;
CompTox Dashboard (EPA)	Tɛmplet:Infobox drug/formatCompTox; Tɛmplet:Infobox drug/formatCompTox;
ATC code	Tɛmplet:Infobox drug/formatATC; Tɛmplet:Infobox drug/formatATC;
Chemical and physical data
Formula	Tɛmplet:Infobox drug/chemical formula
Molar mass	Tɛmplet:Chem molar mass
3D model (JSmol)	Tɛmplet:Infobox drug/formatJmol; Tɛmplet:Infobox drug/formatJmol;
	SMILES CCC(C)C(C(=O)NC(C)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCC(C(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(=O)N)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(C)(C)NC(=O)C(CC6=CN=CN6)N;
	InChI InChI=1S/C187H291N45O59/c1-18-105(10)154(180(282)208-108(13)159(261)216-133(86-114-89-200-119-50-40-39-49-117(114)119)170(272)218-129(82-102(4)5)171(273)228-152(103(6)7)178(280)215-121(53-44-72-199-186(192)193)162(264)201-91-141(242)209-120(52-43-71-198-185(190)191)161(263)204-94-151(257)258)230-172(274)131(83-111-45-33-31-34-46-111)219-167(269)126(64-69-149(253)254)214-166(268)122(51-41-42-70-195-144(245)98-290-79-78-289-76-74-197-145(246)99-291-80-77-288-75-73-196-139(240)66-61-127(183(285)286)211-140(241)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-146(247)248)212-158(260)107(12)206-157(259)106(11)207-165(267)125(60-65-138(189)239)210-142(243)92-202-163(265)123(62-67-147(249)250)213-168(270)128(81-101(2)3)217-169(271)130(85-113-56-58-116(238)59-57-113)220-175(277)135(95-233)223-177(279)137(97-235)224-179(281)153(104(8)9)229-174(276)134(88-150(255)256)221-176(278)136(96-234)225-182(284)156(110(15)237)231-173(275)132(84-112-47-35-32-36-48-112)222-181(283)155(109(14)236)227-143(244)93-203-164(266)124(63-68-148(251)252)226-184(287)187(16,17)232-160(262)118(188)87-115-90-194-100-205-115/h31-36,39-40,45-50,56-59,89-90,100-110,118,120-137,152-156,200,233-238H,18-30,37-38,41-44,51-55,60-88,91-99,188H2,1-17H3,(H2,189,239)(H,194,205)(H,195,245)(H,196,240)(H,197,246)(H,201,264)(H,202,265)(H,203,266)(H,204,263)(H,206,259)(H,207,267)(H,208,282)(H,209,242)(H,210,243)(H,211,241)(H,212,260)(H,213,270)(H,214,268)(H,215,280)(H,216,261)(H,217,271)(H,218,272)(H,219,269)(H,220,277)(H,221,278)(H,222,283)(H,223,279)(H,224,281)(H,225,284)(H,226,287)(H,227,244)(H,228,273)(H,229,276)(H,230,274)(H,231,275)(H,232,262)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,190,191,198)(H4,192,193,199)/t105-,106-,107-,108-,109+,110+,118-,120-,121-,122-,123-,124-,125-,126-,127+,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1; Key:DLSWIYLPEUIQAV-CCUURXOWSA-NTɛmplet:Stdinchicite;

Tɛmplet:Infobox drug/maintenance categories

Semaglutide,bɛ ni lahi n mi tila' shɛli Ozempic la, nyɛla tila' shɛli bɛ ni mali n tibiri type 2 shikiri doro n ti pahi ŋmɛlimbu.^[1] Di nyƐla salo ni bɛ yu shɛli n ti paai Metformin, amaa niri ni tooi kpuɣiri dibaayi maa zaa ^[1]^[2] Di nyƐla din mali yiko ʒim shikiru galisim bee filiŋ yiko ningbuŋ ni ka baligiri suhu ni dɔriti, ka lahi baligiri yaan nina dɔriti.^[1] Tim ŋɔ nyɛla din vaana bee n-chibiri n niŋ ningbuŋ ni^[1]

Doro ŋɔ barina shɛŋa n nye tiri kpuɣibu bee tiri bee binsaa bee puuni biƐrim n ti pahi pu' fɔɣili^[1] Di barina kpɛma shɛ`Na n nye diabetic ketoacidosis bee ʒim shikiri filiŋ bee pancreatitis^[2] Di lahi mali la yɛlimuɣisira n ti paɣa puɣinima ni bihi ban be bɛ ni yaha ka nye bi ni bɛ sahi n ti ni paɣa ŋun mɔɣisiri bia vali^[1] Di nyɛla din tumdi ka ningbuŋ ni kamani glucagon-like-peptide-1 (GLP-1) ka nye din pahiri insulin ningbuŋ ni, ka filindi glucagon mii ka la nye din baligiri bindirigu pulini yibu.^[2]

Semaglutide nyɛla bɛ ni daa saɣi n ti shɛli ni di kpuɣi yuuni 2017 Amɛrika tiŋgbani ni.^[1] Novo Nordisk n daa ŋun mali li^[1] Di nyɛla tuuli GLP-1 tila' shɛli din ni tooi vali noli ni^[3] Din nyɛla din 2mg shɛriga laɣari paai Ghana shiiri 10,200 (850USD) yuuni 2021 puli ni^[4]

References

1 2 3 4 5 6 7 8 9 10 Semaglutide Monograph for Professionals (en). American Society of Health-System Pharmacists.
1 2 3 BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 738. ISBN 978-0-85711-369-6.CS1 maint: date format (link)
↑ "FDA approves first oral GLP-1 treatment for type 2 diabetes" (Press release). FDA. 20 September 2019. Archived from the original on 23 September 2019. Retrieved 20 September 2019.
↑ Ozempic Prices, Coupons & Savings Tips (en-us).

[AHFS2021-1] 1 2 3 4 5 6 7 8 9 10 Semaglutide Monograph for Professionals (en). American Society of Health-System Pharmacists.

[BNF80-2] 1 2 3 BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 738. ISBN 978-0-85711-369-6.CS1 maint: date format (link)

[FDA20192-3] "FDA approves first oral GLP-1 treatment for type 2 diabetes" (Press release). FDA. 20 September 2019. Archived from the original on 23 September 2019. Retrieved 20 September 2019.

[GRx20212-4] Ozempic Prices, Coupons & Savings Tips (en-us).

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