After regulatory network construction and RIF analysis, we found that the TFs: HAND1, PTK1, NFKB1, ZIC3, STAT6, E2F1, PELP1, USF2, CBFB, SOX9, and FOXO4 may play important roles in children's asthma initiation.
In the differentially regulatory network, transcription factors HAND1, PTK1, NFKB1, ZIC3, STAT6, E2F1, PELP1, USF2, CBFB, SOX9, and FOXO4 were found to have altered expression levels in asthma patients.