Molar concentrations were used to facilitate comparison of our results with those from other studies, based on the following molecular weights: DMP 126.0,
DMTP 142.1, DMDTP 158.2, DEP 154.1, DETP 170.2, and DEDTP 186.2 g/mol.
(2015) urinary [40] concentrations of organophosphate insecticides metabolites: TCPY, DEPH, DETP, DEDTP, DMP,
DMTP, DMDTP [ng/ml] Melgarejo et al.
The analysis included six nonspecific metabolites of organophosphates pesticides, that is, DAPs derivatives consisting of DMP, DEP,
DMTP, DMDTP, DEDTP, and DETP.
We assume factor of generalization influences critical thinking and we also believe that individual tasks of
DMTP test are very demanding in terms of critical thinking.
For the individual DAPs, differences in mean urinary DMP (p=0.028) and
DMTP (p=0.005) levels were statistically significant after the conventional and organic phase, and DMDTP levels trended towards significance (p=0.051).
The primary DAP found in the urine was
DMTP, the metabolite of azinphosmethyl and malathion (among others), two pesticides widely used on fruit and vegetable crops.
Six dialkylphosphate (DAP) metabolites of OPs [dimethylphosphate (DMP), dimethylthiophosphate (
DMTP), diethylphosphate (DEP), diethylthiophosphate (DETP), dimethyldithiophosphate (DMDTP) and diethyldithiophosphate (DEDTP)] and three metabolites of PYRs [3-phenoxybenzoic acid (3PBA), trans/cis-3-(2,2-dichlorovinyl)-1-methylcyclopropane1,2-dicarboxylic acid (TDCCA and CDCCA, respectively)] were examined using gas chromatography-mass spectrometry (GC-MS; OP metabolites were analyzed using a PE Clarus 600s/MSD, and PYR metabolites were analyzed using an Agilent 7890B/5977A GC/ MSD) based on the modified method reported by Kuhn et al.
About 75% of the approved OPPs are metabolized to at least one of the 6 commonly measured dialkyl phosphates (DAPs), namely dimethyl phosphate (DMP), diethyl phosphate (DEP), dimethyl thiophosphate (
DMTP), dimethyl dithiophosphate (DMDTP), diethyl thiophosphate (DETP), and diethyl dithiophosphate (DEDTP).
Those measured were three dimethyl (DM) phosphate metabolites--dimethylphosphate (DMP), dimethylthiophosphate (
DMTP), dimethyldithiophosphate (DMDTP); and three diethyl (DE) phosphate metabolites--diethylphosphate (DEP), diethylthiophosphate (DETP), and diethyldithiophosphate (DEDTP).
The proportion of women with values below the detection limit in the pooled sample ranged from 9% for
DMTP to 78% for DEDTP.
One urine sample from each mother and one from each child were analyzed for six nonspecific dialkylphosphate (DAP) metabolites of numerous OP insecticides [diethylphosphate (DEP), diethylthiophosphate (DETP), diethyldithiophosphate (DEDTP), dimethylphosphate (DMP), dimethylthiophosphate (
DMTP), and dimethyldithiophosphate (DMDTP)].